Barcelona city is at the heart of an independence movement in Catalonia, which has already affected the football club.
Barca’s 3-0 win over Las Palmas in October was played behind closed doors following unrest during the controversial independence referendum.
The club has largely stood by Catalonia’s efforts to hold an independence vote but in recent weeks various political chants have been heard at the Nou Camp.
And La Liga president Javier Tebas has threatened to ban fans from another of Barca’s domestic games if the chants continue.
“Offensive chants such as ‘Puta Espana’, ‘Puta Catalunya’, ‘Puta Andalucia’ and similar words have been reported regarding this,” Tebas told reporters.
“Could the Nou Camp be closed as a punishment? Yes, absolutely.
“The procedure would be that the Competition Committee decides on a cause for punishment and if the Administrative Court concur with that then punishments could be handed out.
“Of course, stadium closure is not the only possibility but it is one of the most severe ones.”
Tebas did add, however, that chants supporting independence that do not incite violence will not be punished.
Barcelona are flying high in La Liga right now, having benefitted in part from Real Madrid’s disastrous start to the campaign.
Ernesto Valverde’s side are unbeaten in 12 games, having won 11 and drawn one.
They sit four points off second-place Valencia and 10 ahead of Real Madrid in third.
Lionel Messi and co. travel to Juventus on Wednesday for a crunch Champions League tie in Group D, with a win enough for Barca to secure progression to the knockout stage as group winners.