Khan and Brook looked destined to do battle on more than one occasion over the course of their careers – and fans have repeatedly campaigned to see the all-Brit welterweight showdown.
But egos and poor timing have, so far, put paid to any hopes of seeing the fight get made.
And former lightweight world champion Crolla is not optimistic that it ever well, as he discussed possible opponents for Khan during an exclusive chat with Daily Star Online.
“The Kell Brook fight is always the fight that gets spoken about isn’t it?” the 31-year-old said.
“That would be a fantastic fight. It would be a super showdown – a stadium fight.
“At that weight it’s just to tough to call as well. I’m hearing Kell is going to move up [to light-middleweight] so I’m not sure.
“I’ve always thought, I don’t know what it is, I just never see the fight happening. There’s just disagreements with them both, it’s never really looked close it happening.”
Earlier today it was announced that Brook – whose recent struggles to compete at the 147lb welterweight limit have been well-documented – would make the step up to light-middleweight in March at the Sheffield Arena against an as-yet unnamed opponent.
The move makes it even less likely fans will get their wish of seeing Brook vs Khan – but Crolla eased the disappointment with a trio of mouth-watering fights in its place.
He continued: “If not Kell, the welterweight division is probably the most packed in terms of talent.
“You could look at a rematch with [Danny] Garcia, there’s [Keith] Thurman, there’s [Shawn] Porter – all those make for really good fights.
“But I think first and foremost, Amir’s gotta get back after this [I’m A Celeb] in the New Year and focus solely on his boxing and hopefully we can see the best of Amir still.”
Anthony Crolla spoke exclusively to Daily Star Online after the release of his new book. Million Dollar Crolla: Good Guys Can Win is available to buy now.