Liverpool centre-back Virgil van Dijk is expected to start on his first return to Southampton since his £75million January move.
Fellow defenders Ragnar Klavan and Alberto Moreno have recovered from muscle injuries to take their places in the squad.
Right-back Joe Gomez is unlikely to feature because of a minor knee problem while midfielder Adam Lallana returns after a thigh problem.
Provisional squad: Karius, Alexander-Arnold, Lovren, Van Dijk, Robertson, Henderson, Can, Wijnaldum, Salah, Firmino, Mane, Mignolet, Matip, Klavan, Moreno, Milner, Oxlade-Chamberlain, Lallana, Ings, Solanke.
Southampton manager Mauricio Pellegrino reported no fresh injury problems ahead of Sunday’s match against Liverpool.
Striker Manolo Gabbiadini had been carrying a hip problem last weekend against , where the Italian was an unused substitute in the 3-2 away win.
Charlie Austin, though, remains out as the forward continues to recover from a hamstring injury.
Provisional squad: McCarthy, Stephens, Hoedt, Bertrand, Soares, Ward-Prowse, Boufal, Lemina, Tadic, Romeu, Carrillo, Forster, Yoshida, Davis, Redmond, Hojbjerg, Long, Gabbiadini