Jose Mourinho’s Red Devils beat Derby 2-0 to reach the fourth round of the FA Cup – a competition United must compete for given their shock EFL Cup exit and Man City’s dominance in the league.
Stoke, meanwhile, are in real danger of relegation this season as they sit 18th in the table, but have sacked former United striker Mark Hughes in an attempt to arrest an alarming decline.
However, Mourinho will be wary of the Potters after they secured an impressive 2-2 draw in the reverse fixture earlier this season.
Scroll down for Standard Sport’s comprehensive preview…
Manchester United host Stoke with kick-off scheduled for 8pm on Monday, January 15.
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Zlatan Ibrahimovic remains out of contention with a knee injury, while Eric Bailly is out until March following ankle surgery.
Antonio Valencia is pushing for a return after a hamstring problem, though Michael Carrick remains out after treatment for a heart condition.
Ashley Young will serve the last game of his three-match suspension on Monday night, eamning Luke Shaw is set to continue at left-back.
Man United starting XI: De Gea, Valencia, Jones, Rojo, Shaw, Matic, Pogba, Lingard, Martial, Mata, Lukaku
Stoke starting XI: Butland, Edwards, Zouma, Wimmer, Pieters, Allen, Cameron, Adam, Shaqiri, Crouch, Choupo-Moting