Harrison, 20, has been drafted into the squad following the withdrawals of Ruben Loftus-Cheek and Sheyi Ojo – both through injury.
Harrison, a former youth team player at Manchester United before moving to the United States aged 14, has impressed in Major League Soccer since making his NYCFC debut in May 2016.
The left-footed wideman – who prefers to play from the right – was nominated for the MLS Rookie of the Year award last term, having been the No.1 pick in the 2016 MLS SuperDraft.
The Stoke-born starlet has scored 10 times in 32 games for New York this season.
“I was thrilled when I found out; I was really speechless,” explained Harrison, speaking to NYCFC’s official website.
“It’s an exciting opportunity and one I’m very grateful for. I never thought this would happen when I moved out here when I was 14. It’s a special moment and I’m going to cherish it.
“Every year this league is growing and you only have to watch the games to see that it’s getting better and better every year. I’m so excited to be traveling over and doing the best I can. It’s an honor to represent my country.”
Harrison’s NYCFC manager Patrick Vieira added: “It’s really good news for Jack, it’s really good news for the football club and of course I’m really pleased for him because he’s improved a lot and he loves the game.
“I just want him to enjoy it — it will be a great, positive experience to be surrounded by players who play in the Premier League and I just want him to show how good he is because if the manager called him, it means he deserves it.”
The Young Lions are joint top of their qualifying group with Ukraine after a 1-1 draw with Holland and a 3-0 win over Latvia in their opening games.