West Ham will be looking to follow up their terrific win over Chelsea by beating another top six team.
Despite picking up three points at the weekend the Hammers remained in the bottom three. How David Moyes would love another three points to lift West Ham out of the relegation zone.
Arsenal, who sit sixth in the league, will be desperate to end their dismal away form and pile on the pressure on their top four rivals.
Summer signing Javier Hernandez could return to action after spending five weeks out with a hamstring problem. The Mexican was an unused substitute at the weekend.
Cheikhou Kouyate, who also had a hamstring injury, could return while Edimilson Fernandes faces a late fitness test.
For the Gunners, Aaron Ramsey will be missing after sustaining a hamstring injury against Southampton and Shkodran Mustafi remains sidelined.